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Use of metronidazole in dogs with acute diarrhoea

Clinical Scenario

Mrs Smith brings Horace, a 3 year old male neutered cross breed dog into the clinic because he has had diarrhoea twice overnight and again this morning. During your clinicial exam you find Horace to be bright and alert, you detect no other abnormalities and Mrs Smith reports no signs of haematochezia. Horace's vaccinations are up to date.  Mrs Smith is keen to do the best for Horace, and you wonder whether administering metronidazole would lead to a more rapid resolution of clinical signs.....

3-Part Question (PICO)

[In clinically well dogs with acute idiopathic diarrhoea] does [treatment with oral systemic metronidazole compared to no metronidazole] decrease [time to resolution of clinical signs]?

Search Strategy and Summary of Evidence

Search Strategy

MEDLINE(R) In-Process & Other Non-Indexed Citations and MEDLINE(R) 1946 to Present using the OVID interface

(dog.mp. OR dogs.mp. OR canine.mp. OR canines.mp. OR canis.mp. OR exp Dogs/)

AND

(diarrhoea.mp. OR diarrhea.mp. OR enteritis.mp. OR loose faeces.mp. OR loose feces.mp. OR loose stools.mp. OR loose stool.mp. OR watery faeces.mp. OR watery feces.mp. OR watery stool.mp. OR watery stools.mp. OR exp Diarrhea/ OR exp Enteritis/)

AND

(metronidazole.mp. OR flagyl.mp. OR MTZ.mp. OR exp Metronidazole/)

CAB Abstracts 1910 to Present using the OVID interface

(dog.mp. OR dogs.mp. OR canine.mp. OR canines.mp. OR canis.mp. OR exp Dogs/)

AND

(diarrhoea.mp. OR diarrhea.mp. OR enteritis.mp. OR loose faeces.mp. OR loose feces.mp. OR loose stools.mp. OR loose stool.mp. OR watery faeces.mp. OR watery feces.mp. OR watery stool.mp. OR watery stools.mp. OR exp diarrhoea/ OR exp enteritis/)

AND

(metronidazole.mp. OR flagyl.mp. OR MTZ.mp. OR exp metronidazole/)

Search Outcome

MEDLINE

  • 28 papers found in MEDLINE search
  • 28 papers excluded as they don't meet the PICO question
  • 0 papers excluded as they are in a foreign language
  • 0 papers excluded as they are review articles/in vitro research/conference proceedings
  • 0 total relevant papers from MEDLINE

CAB Abstracts

  • 80 papers found in CAB search
  • 80 papers excluded as they don't meet the PICO question
  • 0 papers excluded as they are in a foreign language
  • 0 papers excluded as they are review articles/in vitro research/conference proceedings
  • 0 total relevant papers from CAB

Total relevant papers

0 relevant papers from both MEDLINE and CAB Abstracts

Comments

No relevant papers were found that directly addressed the PICO question.

Summary of Evidence

No Summary of Evidence yet.

Comments

There were no published articles found directly comparing the treatments of interest in this BET. 

Other resources such as textbooks, expert opinion, narrative reviews and online sites can be useful when peer-reviewed evidence does not exist.  However, there needs to be an appreciation of the limitations for using these evidence sources in decision-making.

There is a need for further research to look at the clinical benefits of using metronidazole in acute idiopathic diarrhoea in order to improve the strength of the evidence base in this area.

Bottom line

There is currently no peer-reviewed evidence to determine whether the use of metronidazole in dogs with acute idiopathic diarrhoea will lead to a clinically significant reduction in the duration of the diarrhoea. 

Therefore, the choice of approach should be based on veterinarian preference, discussion of the risks and benefits with the client and individual practice guidelines, if they are available.

Disclaimer

The BETs on this website are a summary of the evidence found on a topic and are not clinical guidelines. It is the responsibility of the individual veterinary surgeon to ensure appropriate decisions are made based on the specific circumstances of patients under their care, taking into account other factors such as local licensing regulations. Read small print

References

About this BET

First author:
roger holden
Second author:
Marnie Brennan
Institution:

Companion Care (Farnham)

CEVM, University of Nottingham

Search last performed:
2017-06-19 11:20:31
Original publication date:
2017-06-30 11:20:31
Last updated:
2017-06-30 11:20:31
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